| Date | Home | Away | Result |
|---|---|---|---|
| 10/17/25 1:30 PM | Virtus Entella | Sampdoria Genua | 3-1 |
| 10/18/25 8:00 AM | Frosinone Calcio | AC Monza | 0-1 |
| 10/18/25 8:00 AM | Pescara Calcio | Carrarese Calcio 1908 | 2-2 |
| 10/18/25 8:00 AM | Mantova 1911 | FC Südtirol | 1-1 |
| 10/18/25 8:00 AM | AC Reggiana 1919 | SSC Bari | 3-1 |
| 10/18/25 10:15 AM | Juve Stabia | US Avellino | 2-0 |
| 10/18/25 12:30 PM | Spezia Calcio | FC Cesena | 1-2 |
| 10/19/25 8:00 AM | Palermo FC | Modena FC | 1-1 |
| 10/19/25 10:15 AM | FC Empoli | FC Venice | 1-1 |
| 10/19/25 12:30 PM | US Catanzaro 1929 | Padova Calcio | 0-1 |